USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: GRB2_HUMAN USC-OGP 2-DE database:  GRB2_HUMAN GRB2_HUMAN General information about the entry View entry in simple text format Entry name GRB2_HUMAN Primary accession number P62993 Secondary accession number(s) P29354 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Growth factor receptor-bound protein 2; AltName: Full=Adapter protein GRB2; AltName: Full=Protein Ash; AltName: Full=SH2/SH3 adapter GRB2;. Gene name Name=GRB2 Synonyms=ASH Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0528: pI=5.53; Mw=25070 SPOT OGP-0537: pI=5.54; Mw=24120 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0808: pI=5.73; Mw=25497 SPOT OGP-0809: pI=5.57; Mw=25339 Cross-references UniProtKB/Swiss-Prot P62993; GRB2_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name GRB2_HUMAN Primary accession number P62993 Secondary accession number(s) P29354 Q14450 Q63057 Q63059 Sequence was last modified on  August 31, 2004 (version 1) Annotations were last modified on  March 15, 2017 (version 168) Name and origin of the protein Description RecName: Full=Growth factor receptor-bound protein 2; AltName: Full=Adapter protein GRB2; AltName: Full=Protein Ash; AltName: Full=SH2/SH3 adapter GRB2; Gene name Name=GRB2 Synonyms=ASH Encoded on Name=GRB2; Synonyms=ASH Keywords 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Endosome; Golgi apparatus; Host-virus interaction; Nucleus; Phosphoprotein; Reference proteome; Repeat; SH2 domain; SH3 domain. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M96995; AAA58448.1; -; mRNA EMBL X62852; CAA44664.1; -; mRNA EMBL L29511; AAC37549.1; -; mRNA EMBL AF063618; AAC72075.1; -; Genomic_DNA EMBL AF063614; AAC72075.1; JOINED; Genomic_DNA EMBL AF063615; AAC72075.1; JOINED; Genomic_DNA EMBL AF063616; AAC72075.1; JOINED; Genomic_DNA EMBL AF063617; AAC72075.1; JOINED; Genomic_DNA EMBL AF498925; AAM21073.1; -; mRNA EMBL CR541942; CAG46740.1; -; mRNA EMBL AC011933; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL BC000631; AAH00631.1; -; mRNA CCDS CCDS11721.1; -; . CCDS CCDS11722.1; -. [P62993-2]; . PIR A43321; A43321; . RefSeq NP_002077.1; NM_002086.4. [P62993-1]; . RefSeq NP_987102.1; NM_203506.2. [P62993-2]; . UniGene Hs.444356; -; . PDB 1AZE; NMR; -; A=1-56 PDB 1BM2; X-ray; 2.10 A; A=49-163 PDB 1BMB; X-ray; 1.80 A; A=49-168 PDB 1CJ1; X-ray; 3.00 A; A/B/C/D/E/F/G/H/I/J/K/L=57-152 PDB 1FHS; NMR; -; A=53-163 PDB 1FYR; X-ray; 2.40 A; A/B/C/D=50-161 PDB 1GCQ; X-ray; 1.68 A; A/B=159-217 PDB 1GFC; NMR; -; A=159-215 PDB 1GFD; NMR; -; A=159-215 PDB 1GHU; NMR; -; A=60-158 PDB 1GRI; X-ray; 3.10 A; A/B=1-217 PDB 1IO6; NMR; -; A=159-215 PDB 1JYQ; X-ray; 2.00 A; A/B=60-151 PDB 1JYR; X-ray; 1.55 A; A=60-151 PDB 1JYU; X-ray; 2.75 A; A=60-151 PDB 1QG1; NMR; -; E=58-159 PDB 1TZE; X-ray; 2.10 A; E=55-152 PDB 1X0N; NMR; -; A=58-159 PDB 1ZFP; X-ray; 1.80 A; E=56-153 PDB 2AOA; X-ray; 1.99 A; A/B=55-153 PDB 2AOB; X-ray; 1.80 A; A/B/C/D=55-153 PDB 2H46; X-ray; 1.90 A; E=53-162 PDB 2H5K; X-ray; 3.25 A; A/B=53-162 PDB 2HUW; X-ray; 1.90 A; A/B=53-162 PDB 2VVK; X-ray; 1.60 A; A=161-214 PDB 2VWF; X-ray; 1.58 A; A=159-214 PDB 2W0Z; X-ray; 1.70 A; A=159-214 PDB 3C7I; X-ray; 1.70 A; A=53-162 PDB 3IMD; X-ray; 2.00 A; A/B=53-163 PDB 3IMJ; X-ray; 2.02 A; A/B=53-163 PDB 3IN7; X-ray; 2.00 A; A/C=53-163 PDB 3IN8; X-ray; 1.70 A; A=53-163 PDB 3KFJ; X-ray; 2.02 A; A=53-163 PDB 3MXC; X-ray; 2.00 A; A=55-152 PDB 3MXY; X-ray; 2.30 A; A=55-152 PDB 3N7Y; X-ray; 2.02 A; A/B/C=55-152 PDB 3N84; X-ray; 2.00 A; A/B/C/D/E/F=53-163 PDB 3N8M; X-ray; 2.00 A; A=53-163 PDB 3OV1; X-ray; 1.60 A; A=53-163 PDB 3OVE; X-ray; 1.82 A; A=53-163 PDB 3S8L; X-ray; 1.71 A; A=53-163 PDB 3S8N; X-ray; 1.71 A; A=53-163 PDB 3S8O; X-ray; 1.85 A; A=53-163 PDB 3WA4; X-ray; 1.35 A; A=60-152 PDB 4P9V; X-ray; 1.64 A; A=53-163 PDB 4P9Z; X-ray; 1.80 A; A=53-163 PDB 5CDW; X-ray; 2.60 A; A/B/C/E/G/H/K/L/O/P/U/V/Y/Z/c/d=54-153 PDBsum 1AZE; -; . PDBsum 1BM2; -; . PDBsum 1BMB; -; . PDBsum 1CJ1; -; . PDBsum 1FHS; -; . PDBsum 1FYR; -; . PDBsum 1GCQ; -; . PDBsum 1GFC; -; . PDBsum 1GFD; -; . PDBsum 1GHU; -; . PDBsum 1GRI; -; . PDBsum 1IO6; -; . PDBsum 1JYQ; -; . PDBsum 1JYR; -; . PDBsum 1JYU; -; . PDBsum 1QG1; -; . PDBsum 1TZE; -; . PDBsum 1X0N; -; . PDBsum 1ZFP; -; . PDBsum 2AOA; -; . PDBsum 2AOB; -; . PDBsum 2H46; -; . PDBsum 2H5K; -; . PDBsum 2HUW; -; . PDBsum 2VVK; -; . PDBsum 2VWF; -; . PDBsum 2W0Z; -; . PDBsum 3C7I; -; . PDBsum 3IMD; -; . PDBsum 3IMJ; -; . PDBsum 3IN7; -; . PDBsum 3IN8; -; . PDBsum 3KFJ; -; . PDBsum 3MXC; -; . PDBsum 3MXY; -; . PDBsum 3N7Y; -; . PDBsum 3N84; -; . PDBsum 3N8M; -; . PDBsum 3OV1; -; . PDBsum 3OVE; -; . PDBsum 3S8L; -; . PDBsum 3S8N; -; . PDBsum 3S8O; -; . PDBsum 3WA4; -; . PDBsum 4P9V; -; . PDBsum 4P9Z; -; . PDBsum 5CDW; -; . DisProt DP00210; -; . ProteinModelPortal P62993; -; . SMR P62993; -; . BioGrid 109142; 534; . DIP DIP-29229N; -; . IntAct P62993; 771; . MINT MINT-91952; -; . STRING 9606.ENSP00000339007; -; . BindingDB P62993; -; . ChEMBL CHEMBL3663; -; . DrugBank DB00061; Pegademase bovine; . iPTMnet P62993; -; . PhosphoSitePlus P62993; -; . BioMuta GRB2; -; . DMDM 51702266; -; . OGP P62993; -; . SWISS-2DPAGE P62993; -; . EPD P62993; -; . MaxQB P62993; -; . PaxDb P62993; -; . PeptideAtlas P62993; -; . PRIDE P62993; -; . TopDownProteomics P62993-1; -. [P62993-1]; . TopDownProteomics P62993-2; -. [P62993-2]; . DNASU 2885; -; . Ensembl ENST00000316615; ENSP00000317360; ENSG00000177885. [P62993-2]; . Ensembl ENST00000316804; ENSP00000339007; ENSG00000177885. [P62993-1]; . Ensembl ENST00000392562; ENSP00000376345; ENSG00000177885. [P62993-1]; . Ensembl ENST00000392563; ENSP00000376346; ENSG00000177885. [P62993-2]; . Ensembl ENST00000392564; ENSP00000376347; ENSG00000177885. [P62993-1]; . GeneID 2885; -; . KEGG hsa:2885; -; . UCSC uc002jnx.5; human; . CTD 2885; -; . DisGeNET 2885; -; . GeneCards GRB2; -; . HGNC HGNC:4566; GRB2; . HPA CAB002589; -; . HPA HPA030749; -; . HPA HPA030750; -; . MIM 108355; gene; . neXtProt NX_P62993; -; . OpenTargets ENSG00000177885; -; . PharmGKB PA28962; -; . eggNOG KOG3601; Eukaryota; . eggNOG ENOG410XR1G; LUCA; . GeneTree ENSGT00820000126999; -; . HOGENOM HOG000251625; -; . HOVERGEN HBG005404; -; . InParanoid P62993; -; . KO K04364; -; . OMA YDFTPQE; -; . OrthoDB EOG091G0HWS; -; . PhylomeDB P62993; -; . TreeFam TF354288; -; . Reactome R-HSA-109704; PI3K Cascade; . Reactome R-HSA-112412; SOS-mediated signalling; . Reactome R-HSA-114604; GPVI-mediated activation cascade; . Reactome R-HSA-1236382; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; . Reactome R-HSA-1250196; SHC1 events in ERBB2 signaling; . Reactome R-HSA-1250347; SHC1 events in ERBB4 signaling; . Reactome R-HSA-1257604; PIP3 activates AKT signaling; . Reactome R-HSA-1295596; Spry regulation of FGF signaling; . Reactome R-HSA-1433557; Signaling by SCF-KIT; . Reactome R-HSA-1433559; Regulation of KIT signaling; . Reactome R-HSA-167044; Signalling to RAS; . Reactome R-HSA-179812; GRB2 events in EGFR signaling; . Reactome R-HSA-180292; GAB1 signalosome; . Reactome R-HSA-180336; SHC1 events in EGFR signaling; . Reactome R-HSA-182971; EGFR downregulation; . Reactome R-HSA-1839117; Signaling by cytosolic FGFR1 fusion mutants; . Reactome R-HSA-186763; Downstream signal transduction; . Reactome R-HSA-1963640; GRB2 events in ERBB2 signaling; . Reactome R-HSA-1963642; PI3K events in ERBB2 signaling; . Reactome R-HSA-2029482; Regulation of actin dynamics for phagocytic cup formation; . Reactome R-HSA-210993; Tie2 Signaling; . Reactome R-HSA-2179392; EGFR Transactivation by Gastrin; . Reactome R-HSA-2219530; Constitutive Signaling by Aberrant PI3K in Cancer; . Reactome R-HSA-2424491; DAP12 signaling; . Reactome R-HSA-2428933; SHC-related events triggered by IGF1R; . Reactome R-HSA-2730905; Role of LAT2/NTAL/LAB on calcium mobilization; . Reactome R-HSA-2871796; FCERI mediated MAPK activation; . Reactome R-HSA-2871809; FCERI mediated Ca+2 mobilization; . Reactome R-HSA-354194; GRB2:SOS provides linkage to MAPK signaling for Integrins; . Reactome R-HSA-375165; NCAM signaling for neurite out-growth; . Reactome R-HSA-388841; Costimulation by the CD28 family; . Reactome R-HSA-389359; CD28 dependent Vav1 pathway; . Reactome R-HSA-391160; Signal regulatory protein (SIRP) family interactions; . Reactome R-HSA-392451; G beta:gamma signalling through PI3Kgamma; . Reactome R-HSA-512988; Interleukin-3; 5 and GM-CSF signaling; . Reactome R-HSA-5637810; Constitutive Signaling by EGFRvIII; . Reactome R-HSA-5654688; SHC-mediated cascade:FGFR1; . Reactome R-HSA-5654689; PI-3K cascade:FGFR1; . Reactome R-HSA-5654693; FRS-mediated FGFR1 signaling; . Reactome R-HSA-5654695; PI-3K cascade:FGFR2; . Reactome R-HSA-5654699; SHC-mediated cascade:FGFR2; . Reactome R-HSA-5654700; FRS-mediated FGFR2 signaling; . Reactome R-HSA-5654704; SHC-mediated cascade:FGFR3; . Reactome R-HSA-5654706; FRS-mediated FGFR3 signaling; . Reactome R-HSA-5654710; PI-3K cascade:FGFR3; . Reactome R-HSA-5654712; FRS-mediated FGFR4 signaling; . Reactome R-HSA-5654719; SHC-mediated cascade:FGFR4; . Reactome R-HSA-5654720; PI-3K cascade:FGFR4; . Reactome R-HSA-5654726; Negative regulation of FGFR1 signaling; . Reactome R-HSA-5654727; Negative regulation of FGFR2 signaling; . Reactome R-HSA-5654732; Negative regulation of FGFR3 signaling; . Reactome R-HSA-5654733; Negative regulation of FGFR4 signaling; . Reactome R-HSA-5655253; Signaling by FGFR2 in disease; . Reactome R-HSA-5655291; Signaling by FGFR4 in disease; . Reactome R-HSA-5655302; Signaling by FGFR1 in disease; . Reactome R-HSA-5663213; RHO GTPases Activate WASPs and WAVEs; . Reactome R-HSA-5673001; RAF/MAP kinase cascade; . Reactome R-HSA-6807004; Negative regulation of MET activity; . Reactome R-HSA-6811558; PI5P; PP2A and IER3 Regulate PI3K/AKT Signaling; . Reactome R-HSA-74749; Signal attenuation; . Reactome R-HSA-74751; Insulin receptor signalling cascade; . Reactome R-HSA-8851805; MET activates RAS signaling; . Reactome R-HSA-8851907; MET activates PI3K/AKT signaling; . Reactome R-HSA-8853334; Signaling by FGFR3 fusions in cancer; . Reactome R-HSA-8853338; Signaling by FGFR3 point mutants in cancer; . Reactome R-HSA-8853659; RET signaling; . Reactome R-HSA-8856825; Cargo recognition for clathrin-mediated endocytosis; . Reactome R-HSA-8856828; Clathrin-mediated endocytosis; . Reactome R-HSA-8865999; MET activates PTPN11; . Reactome R-HSA-8875360; InlB-mediated entry of Listeria monocytogenes into host cell; . Reactome R-HSA-8875555; MET activates RAP1 and RAC1; . Reactome R-HSA-8875656; MET receptor recycling; . Reactome R-HSA-912526; Interleukin receptor SHC signaling; . Reactome R-HSA-912631; Regulation of signaling by CBL; . Reactome R-HSA-983695; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; . SignaLink P62993; -; . SIGNOR P62993; -; . ChiTaRS GRB2; human; . EvolutionaryTrace P62993; -; . GeneWiki GRB2; -; . GenomeRNAi 2885; -; . PRO PR:P62993; -; . Proteomes UP000005640; Chromosome 17; . Bgee ENSG00000177885; -; . CleanEx HS_GRB2; -; . ExpressionAtlas P62993; baseline and differential; . Genevisible P62993; HS; . GO GO:0005911; C:cell-cell junction; IEA:Ensembl; . GO GO:0008180; C:COP9 signalosome; IDA:UniProtKB; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; TAS:HGNC; . GO GO:0005768; C:endosome; IDA:UniProtKB; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IBA:GO_Central; . GO GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell; . GO GO:0070436; C:Grb2-EGFR complex; IDA:BHF-UCL; . GO GO:0005730; C:nucleolus; IDA:HPA; . GO GO:0005654; C:nucleoplasm; IDA:HPA; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0005886; C:plasma membrane; TAS:Reactome; . GO GO:0012506; C:vesicle membrane; IEA:Ensembl; . GO GO:0016303; F:1-phosphatidylinositol-3-kinase activity; TAS:Reactome; . GO GO:0046875; F:ephrin receptor binding; IPI:UniProtKB; . GO GO:0005154; F:epidermal growth factor receptor binding; IPI:UniProtKB; . GO GO:0042802; F:identical protein binding; IPI:IntAct; . GO GO:0043560; F:insulin receptor substrate binding; IPI:UniProtKB; . GO GO:0005168; F:neurotrophin TRKA receptor binding; IPI:UniProtKB; . GO GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IBA:GO_Central; . GO GO:0046934; F:phosphatidylinositol-4; 5-bisphosphate 3-kinase activity; TAS:Reactome GO GO:0019901; F:protein kinase binding; IPI:BHF-UCL; . GO GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; TAS:Reactome; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0017124; F:SH3 domain binding; IDA:UniProtKB; . GO GO:0005070; F:SH3/SH2 adaptor activity; TAS:UniProtKB; . GO GO:0007568; P:aging; IEA:Ensembl; . GO GO:0048646; P:anatomical structure formation involved in morphogenesis; IEA:Ensembl; . GO GO:0007411; P:axon guidance; TAS:Reactome; . GO GO:0060670; P:branching involved in labyrinthine layer morphogenesis; IEA:Ensembl; . GO GO:0030154; P:cell differentiation; IBA:GO_Central; . GO GO:0016477; P:cell migration; IBA:GO_Central; . GO GO:0007267; P:cell-cell signaling; TAS:UniProtKB; . GO GO:0071479; P:cellular response to ionizing radiation; IMP:BHF-UCL; . GO GO:0035635; P:entry of bacterium into host cell; TAS:Reactome; . GO GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:UniProtKB; . GO GO:0038128; P:ERBB2 signaling pathway; TAS:Reactome; . GO GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome; . GO GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome; . GO GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome; . GO GO:0045087; P:innate immune response; IBA:GO_Central; . GO GO:0008286; P:insulin receptor signaling pathway; IPI:UniProtKB; . GO GO:0050900; P:leukocyte migration; TAS:Reactome; . GO GO:0000165; P:MAPK cascade; TAS:Reactome; . GO GO:0061024; P:membrane organization; TAS:Reactome; . GO GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome; . GO GO:0038083; P:peptidyl-tyrosine autophosphorylation; IBA:GO_Central; . GO GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:Reactome; . GO GO:0030838; P:positive regulation of actin filament polymerization; IEA:Ensembl; . GO GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IMP:BHF-UCL; . GO GO:0051291; P:protein heterooligomerization; IEA:Ensembl; . GO GO:0007265; P:Ras protein signal transduction; TAS:UniProtKB; . GO GO:0031623; P:receptor internalization; IMP:BHF-UCL; . GO GO:0042127; P:regulation of cell proliferation; IBA:GO_Central; . GO GO:0043408; P:regulation of MAPK cascade; IEA:Ensembl; . GO GO:0014066; P:regulation of phosphatidylinositol 3-kinase signaling; TAS:Reactome; . GO GO:0042770; P:signal transduction in response to DNA damage; IMP:BHF-UCL; . GO GO:0031295; P:T cell costimulation; TAS:Reactome; . GO GO:0016032; P:viral process; IEA:UniProtKB-KW; . Gene3D 3.30.505.10; -; 1; . InterPro IPR000980; SH2; . InterPro IPR001452; SH3_domain; . Pfam PF00017; SH2; 1; . Pfam PF00018; SH3_1; 2; . PRINTS PR00401; SH2DOMAIN; . PRINTS PR00452; SH3DOMAIN; . SMART SM00252; SH2; 1; . SMART SM00326; SH3; 2; . SUPFAM SSF50044; SSF50044; 2; . SUPFAM SSF55550; SSF55550; 2; . PROSITE PS50001; SH2; 1; . PROSITE PS50002; SH3; 2; .

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